Two enzymes which phosphorylate neomycin and kanamycin in Escherichia coli strains carrying R factors.

نویسندگان

  • M Brzezinska
  • J Davies
چکیده

Two enzymes which phosphorylate neomycin and kanamycin have been detected in Escherichia coli strains carrying R factors. Neomycin-kanamycin phosphotransferase I can phosphorylate neomycin and kanamycin, but not butirosin. Neomycin-kanamycin phosphotransferase II can phosphorylate all three antibiotics. The enzymes also differ in their response to certain inhibitors of phosphorylation. Neomycin-kanamycin phosphotransferase II is found in certain strains of Pseudomonas aeruginosa.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 3 2  شماره 

صفحات  -

تاریخ انتشار 1973